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Example Content from MEDITEXT for Glucagon:
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ACUTE EXPOSURE INFORMATION
- USES: Glucagon is indicated for the treatment of severe hypoglycemia, and to treat beta blocker overdose and less commonly calcium channel blocker overdose. It may also be used as a diagnostic aid and to treat esophageal foreign bodies.
- PHARMACOLOGY: Glucagon induces liver glycogen breakdown, releasing glucose from the liver. Hepatic stores of glycogen are needed for glucagon to produce an antihypoglycemic effect. Binding of glucagon to receptors on the heart stimulates conversion of DTP to cyclic AMP, which increases heart rate and strength of contraction.
- EPIDEMIOLOGY: Overdose is uncommon.
- WITH THERAPEUTIC USE
- ADVERSE EFFECTS: Nausea and vomiting may be expected. Severe reactions are not anticipated. Reactive hypoglycemia can develop following the administration of glucagon. Hypokalemia may also occur. Acute allergic reactions (including urticaria, respiratory distress, and hypotension) have been reported rarely following intravenous administration.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Symptoms of nausea, vomiting, gastric hypotonicity and diarrhea would be expected following overdose. Toxicity is anticipated to be an extension of adverse events reported and may include: hyperglycemia or hypoglycemia, hypokalemia, and an increase in blood pressure.
- SEVERE TOXICITY: Based on its short half-life, significant protracted overdose effects are not expected to develop.
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