RightAnswer Knowledge Solutions Search Results for Fosphenytoin

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    1. Dysrhythmias and hypotension have rarely occurred (estimated 1 adverse cardiac event per 200,000 administrations) with therapeutic administration of fosphenytoin. Propylene glycol is not used as a diluent in fosphenytoin (unlike phenytoin), a cardiac effect from its metabolites (largely phenytoin) is the presumed mechanism.
    1. Toxic effects are rare at plasma concentrations less than 20 mcg/mL (80 mcmol/L), but are common in patients with plasma concentrations greater than 30 mcg/mL (120 mcmol/L).
    1. Common effects include nystagmus, ataxia, dysarthria, mild sedation and CNS depression. Ophthalmoplegia, hyperreflexia, mental status changes, hallucinations, and in severe cases, coma may also occur.
    1. Hypotension, bradycardia and asystole have resulted from intravenous overdoses of fosphenytoin (NO propylene glycol diluent).
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