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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Clofarabine:
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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- The following adverse effects have been reported: anemia, leukopenia, thrombocytopenia, neutropenia, febrile neutropenia, N/V, diarrhea, abdominal pain, constipation, gingival bleeding, infectious disease, headache, rigor, hepatotoxicity, tachycardia, hypertension, hypotension, fatigue, lethargy, injection site pain, fever, anorexia, arthralgia, back pain, myalgia, dizziness, somnolence, tremor, anxiety, depression, hematuria, cough, dyspnea, epistaxis, contusion, dermatitis, pruritus, erythema, palmar-plantar erythrodysesthesia syndrome, petechiae, flushing. Systemic inflammatory response syndrome or capillary leak syndrome with symptoms of rapid onset respiratory distress, hypotension, pleural effusions, pericardia effusion, and multi-organ failure have been reported in patients.
- WITH POISONING/EXPOSURE
- Overdose data are limited. Effects are expected to be an extension of adverse effects reported with therapeutic use. Grade 4 hyperbilirubinemia, grade 2 and 3 vomiting, and grade 3 maculopapular rash developed in 2 pediatric patients with ALL after receiving clofarabine 70 mg/m(2)/day for 5 days, the highest daily dose administered to a human to date (on a mg/m(2) basis).
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