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|Example of Acute Exposure data from MEDITEXT.|
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Example Content from MEDITEXT for Ammonium Perfluorooctanoate:
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ACUTE EXPOSURE INFORMATION
- WITH POISONING/EXPOSURE
- There is little human data regarding adverse health effects from acute exposure to ammonium perfluorooctanoate (APFO). Based on animal studies, APFO is considered moderately toxic following acute exposure and is an ocular irritant. APFO may cause cough, sneezing, nasal discharge, headache, hoarseness, nasal and throat pain and other signs of upper respiratory tract irritation if inhaled. Mild skin irritation may occur following dermal contact.
- In biologic media, APFO quickly dissociates to perfluorooctanoate which is the anion of perfluorooctanoic acid (PFOA). This management will address APFO when possible, but because of lack of data will also include information regarding PFOA. Perfluorooctanoic acid and its salts (APFO) are commonly referred to collectively.
- Occupational studies in humans have found higher organic fluoride concentrations in workers exposed to ammonium perfluorooctanoate, but no adverse health effects attributable to exposure have been seen. It is thought that the general population may be exposed to low levels of APFO, but it has not yet been determined how exposure occurs.
- In animal studies, chronic exposure by dermal, oral or inhalation primarily affects the liver. Increased liver weights and hepatocellular changes have been observed. Leydig cell tumors, mammary fibroadenomas and pancreatic acinar cell tumors have been reported in rats, but this is thought to be related to hepatic peroxisome proliferation. Peroxisome proliferation is thought to be species specific with humans predominantly nonresponsive.
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