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ACUTE EXPOSURE INFORMATION
- WITH POISONING/EXPOSURE
- Toxic effects depend on the duration, total dose and rate of exposure. The effects of acute high-dose exposure may be delayed in onset for several hours. Following large exposures, these include somnolence, confusion, hallucinations, disorientation, incoordination, tremors, and possibly seizures with cardiovascular collapse. Peripheral neuropathy may appear several weeks following significant acute exposure or following significant chronic exposures. Encephalopathy may occur in severe acute poisonings.
- In sub-acute toxicity (exposure over days to weeks), and if of sufficient concentration, drowsiness, somnolence, loss of concentration, truncal ataxia, dysarthria, nystagmus, and urinary retention may occur. Polyneuropathy and peripheral neuropathy, with mainly motor and proprioceptive disturbances, may follow several weeks later.
- Neurotoxic effects may include muscle weakness, numbness of limbs and extremities, tingling fingers, speech difficulties, unsteadiness, tremors, fatigue, lethargy, memory difficulties, and a sensory polyneuropathy if of sufficient dose. Excessive sweating is also common after exposure.
- Dermal contact is a common route of exposure and may result in skin irritation with numbness, tingling, blistering and peeling with direct contact of high concentrations. Visual impairment and eye irritation also occur with significant exposure. Inhalation may produce a cough and sore throat. Ingestion, the least common route, may result in abdominal pain.
- Complete recovery over a few weeks to months may be expected with mild symptoms, including prolonged weakness, but in cases of severe exposure, gradual and incomplete recovery may occur with residual ataxia, loss of reflexes, distal extremity weakness, and sensory disturbances.
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