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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- The most frequently occurring adverse effects following dantrolene therapy include drowsiness, dizziness, weakness, fatigue, and diarrhea. Other adverse effects that may occur following therapeutic administration of dantrolene include pericarditis, pleural effusion with peripheral and pleural eosinophilia, nausea, vomiting, abdominal pain, bowel obstruction, and rarely, hallucinations. Aplastic anemia, leukopenia, and heart failure have occurred with oral use .
- Fatal and non-fatal hepatitis have been reported with prolonged dantrolene therapy. Fatalities appear to be associated with the following factors: patient age over 30 years, duration of use over 2 months, female gender, higher daily doses (300 mg or more), concomitant drugs and disease, and higher bilirubin levels.
- WITH POISONING/EXPOSURE
- Dantrolene overdose data are limited. Muscular weakness, lethargy, coma, vomiting, diarrhea, and crystalluria may occur in the event of an overdose.
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