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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- The following adverse effects have been reported with the use of edetate calcium disodium: Inverted T waves and cardiac rhythm irregularities, transient decreases in blood pressure, acute necrosis of the proximal tubules, microscopic hematuria, glycosuria, proteinuria, nephrotoxicity, acute renal failure, dermatitis and exfoliative dermatitis of the scrotum, injection site pain following intramuscular injection, hypocalcemia, hypercalcemia, nausea, vomiting, abdominal pain, diarrhea, mild elevations in SGOT and SGPT, anemia, bone marrow depression, fatigue, myalgia, zinc deficiency, headache, tremors, numbness, and tingling.
- In patients with lead encephalopathy, edetate calcium disodium may worsen cerebral edema. For patients with lead encephalopathy, edetate calcium disodium should be begun 4 hours after administration of dimercaprol.
- WITH POISONING/EXPOSURE
- No ill effects were observed following inadvertent administration of 5 times the recommended dose, infused intravenously over a 24-hour period of time, to an asymptomatic 16-month-old with a blood lead level of 56 mcg/dL
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