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ACUTE EXPOSURE INFORMATION
- Coumatetralyl is a derivative of 4-hydroxycoumarin. In massive overdose, these agents have produced rapid and persistent hypoprothrombinemia and associated bleeding diathesis. Once coagulation defects occur, they may persist for 6 weeks to many months. Because it has an elimination half-life of several days, daily exposures would produce cumulative toxicity. No chronic data were found for coumatetralyl in humans, however. This review is based on the properties of coumarin and other long-acting anticoagulants.
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