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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Therapeutic doses of physostigmine have resulted in cholinergic crisis: seizures, bradycardia/asystole, nausea/vomiting, sweating, hypersalivation, bronchospasm, or pulmonary edema.
- Risk of cholinergic crisis is greatest in the following circumstances:
- If physostigmine is given in the absence of anticholinergic symptoms,
- If physostigmine is used to treat tricyclic or tetracyclic antidepressant overdose,
- If physostigmine dose is too high.
- WITH POISONING/EXPOSURE
- If physostigmine dose is too high, cholinergic crisis may result. Cholinergic crisis can include: seizures, bradycardia/asystole, nausea/vomiting/diarrhea, sweating, hypothermia, hypersalivation, bronchospasm, respiratory depression, or pulmonary edema. Death may occur due to respiratory failure.
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