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ACUTE EXPOSURE INFORMATION
- USES: Mitotane is indicated for the treatment of inoperable functional and non-functional adrenal cortical carcinoma.
- PHARMACOLOGY: The exact mechanism of action of mitotane is not known. It does cause cytotoxic atrophy of the adrenal cells which is associated with unresponsiveness to ACTH administration. In addition, mitotane, in an independent manner, appears to alter the pattern of corticoid metabolism. Mitotane reduced the excretion of 17-hydroxycorticosteroids without concomitant reductions in plasma cortisol or cortisol secretion rates, as well as, increased the formation of 6-beta-hydroxyl cortisol.
- EPIDEMIOLOGY: Overdose is rare.
- WITH THERAPEUTIC USE
- COMMON; about 80%: Anorexia, nausea, vomiting, anorexia, diarrhea; 15% to 40%: CNS depression (eg; lethargy, somnolence, dizziness or vertigo), and skin rashes. INFREQUENT: Ocular effects (eg, blurred vision, diplopia, lens opacity, and retinopathy), hematuria, hemorrhagic cystitis, albuminuria, hypertension, orthostatic hypotension, flushing, and hyperpyrexia.
- WITH POISONING/EXPOSURE
- Overdose data are limited. Overdose effects are anticipated to be an extension of adverse effects observed following therapeutic doses.
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