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ACUTE EXPOSURE INFORMATION
- USES: Letrozole is used to treat postmenopausal women with breast cancers.
- PHARMACOLOGY: Letrozole is a nonsteroidal competitive inhibitor of aromatase and thus, in postmenopausal women, inhibits conversion of adrenal androgens (primarily androstenedione and testosterone) to estrogens (estrone and estradiol) in peripheral tissues and cancer tissue. As a result, letrozole interferes with estrogen-induced stimulation or maintenance of growth of hormonally responsive (estrogen and/or progesterone receptor positive or receptor unknown) breast cancers.
- EPIDEMIOLOGY: Overdose is rare.
- WITH THERAPEUTIC USE
- COMMON (more than 20%): Hot flashes, arthralgia, flushing, asthenia, edema, bone pain, headache, dizziness, hypercholesterolemia, and increased sweating. OTHER EFFECTS: Nausea, vomiting, diarrhea, anorexia, dyspepsia, abdominal pain, constipation, hypertension, chest pain, rash, alopecia, vaginal discharge, bleeding, and irritation, urinary tract infection, elevated liver enzymes, muscle pain, joint pain, back pain, limb pain, fatigue, insomnia, dyspnea, and cough. Pancytopenia, leukopenia, and peripheral thromboembolic events, such as venous thrombosis, thrombophlebitis, portal vein thrombosis, and pulmonary embolism have rarely been reported in clinical trials and postmarketing reports, however, cause and effect relationships have not been established. Letrozole is classified as pregnancy category X.
- WITH POISONING/EXPOSURE
- TOXICITY: Overdose data are limited. Overdose effects are anticipated to be an extension of adverse effects following therapeutic doses. In isolated cases of letrozole overdose, the highest single dose of 62.5 mg or 25 tablets did not result in serious adverse effects.
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