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ACUTE EXPOSURE INFORMATION
- Phenylthiourea is a bitter or tasteless (depending on the individual's genetic background) needle- or prism-like solid material used in medical genetics studies, as a repellent for rats, rabbits, and weasels, and in the production of rodenticides. It can be absorbed by ingestion and parenterally; it may be absorbed and cause systemic toxicity following inhalation or dermal exposure.
- Phenylthiourea is an experimental teratogen in mice.
- Vomiting, noisy or difficult breathing, cyanosis, and hypothermia may occur. Pleural effusions and pulmonary edema have been seen in exposed experimental animals, and this compound destroys cytochrome P450 in vivo. Hypoglycemia lasting for up to 5 hours was seen in rats injected with phenylthiourea.
- Phenylthiourea inhibited rat lung acetylcholinesterase and is a potent inhibitor of melanin synthesis in vitro, but there is no evidence that cholinesterase or melanin synthesis inhibition are its mechanisms of action in exposed humans.
- Phenylthiourea releases toxic and irritating fumes of oxides of nitrogen and sulfur when heated to decomposition. Inhalation exposure to such fumes would be predicted to result in respiratory tract irritation with bronchospasm, chemical pneumonitis, or noncardiogenic pulmonary edema.
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