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ACUTE EXPOSURE INFORMATION
- Terephthalic Acid is a mild respiratory tract and eye irritant. In experimental animals, it is mildly toxic by the intraperitoneal and intravenous routes.
- In general, phthalate compounds are of a low order of toxicity among chemicals used in industrial settings. They are not appreciably absorbed by the dermal or inhalation routes.
- Terephthalic acid causes aciduria, elevated calcium and magnesium excretion, and slightly elevated serum magnesium and calcium levels in rats.
- Terephthalic acid induced urinary bladder calculi and urinary system transitional cell hyperplasia in experimental animals.
- In dogs, sublethal terephthalic acid injection caused a decrease in aortic blood pressure.
- In rats chronically exposed to terephthalic acid, a decreased uptake of norepinephrine by grey matter snyaptosomes and activation of catechol-O-methyl-transferase and monoamine oxidase in the cerebral hemispheres has been noted.
- When heated to decomposition, terephthalic acid may release irritating fumes and acrid smoke which might cause respiratory tract irritation if inhaled.
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