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ACUTE EXPOSURE INFORMATION
- USES: An antimalarial agent, effective as a tissue schizonticide, indicated for the radical cure (prevention of relapse) of vivax malaria.
- PHARMACOLOGY: Primaquine is an 8-aminoquinoline compound that eliminates exoerythrocytic (tissue) infection, thereby preventing the development of the erythrocytic forms of the parasite responsible for relapses in vivax malaria.
- TOXICOLOGY: Primaquine is an oxidizing agent that can cause methemoglobinemia or hemolytic anemia, especially in susceptible populations.
- EPIDEMIOLOGY: Primaquine overdose is rare in the United States, but may be common in areas where malaria is endemic.
- WITH THERAPEUTIC USE
- COMMON: Nausea, vomiting, and abdominal cramps are frequently reported with primaquine therapy.
- WITH POISONING/EXPOSURE
- MILD TO MODERATE TOXICITY: Nausea, abdominal pain, and headaches have occurred at doses of 60 to 240 mg/day.
- SEVERE TOXICITY: Hematologic effects, including methemoglobinemia, hemolytic anemia, leukopenia, and granulocytopenia, have been reported following high doses of primaquine.
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