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ACUTE EXPOSURE INFORMATION
- WITH THERAPEUTIC USE
- Tizanidine, an imidazole derivative, is a centrally acting alpha-2 adrenergic agonist structurally related to clonidine, but possesses only 1/10 to 1/50 of clonidine's potency. It may also be selective for imidazoline-receptors. It has been reported that tizanidine 12 mg has sedative and sympatholytic effects comparable with clonidine 150 micrograms. Dry mouth, somnolence, asthenia, dizziness and mild hypotension are common adverse effects following the therapeutic use of tizanidine. Bradycardia, palpitations, ventricular extrasystoles, rash, sweating, skin ulcer, pruritus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, constipation, elevated liver enzymes, back pain, lethargy, drowsiness, insomnia, headache, anxiety, syncope, tremor, depression, weakness, paresthesia, visual hallucinations, and fever are uncommon adverse effects.
- WITH POISONING/EXPOSURE
- Following an overdose, tizanidine may cause alterations of mental status, lethargy, bradycardia, hypotension, agitation, confusion, drowsiness, vomiting, miosis, coma, or respiratory depression. Sinus bradycardia (HR 34 beats/minute), first degree AV block, and Wenckebach type second degree AV block were reported in a woman who ingested 120 mg tizanidine and 30 mg lorazepam.
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